Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of transfusion
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چکیده
منابع مشابه
Addition of Sodium Pyruvate to Stored Red Blood Cells Attenuates Liver Injury in a Murine Transfusion Model
RBCs undergo numerous changes during storage and stored RBCs may induce adverse effects, ultimately resulting in organ injury in transfusion recipients. We tested the hypothesis that the addition of SP to stored RBCs would improve the quality of the stored RBCs and mitigate liver injury after transfusion in a murine model. RBCs were harvested from C57BL/6J mice and stored for 14 days in CPDA-1 ...
متن کاملAddition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization.
BACKGROUND The storage of red blood cells (RBCs) results in numerous changes, which over time result in decreased recovery of transfused RBCs. In addition (at least in animal models), stored RBCs can be more immunogenic and also stimulate the systemic release of inflammatory cytokines in transfusion recipients. One component of the RBC storage lesion is the accumulation of oxidative damage. We ...
متن کاملA Root Cause Analysis of Haemolysis Encountered in Leuco-filtration of Stored Packed Red Cells Units
Background and Aims: Leukoreduction of blood components has reduced the incidence of transfusion-associated adverse events. Leucofiltration is the most effective method of leukoreduction. We encountered haemolysis in a series of leucofiltered units. This stressed our precious inventory, added to financial loss, increased our turn-around time to issue leucofiltered blood units, and placed doubts...
متن کاملMicroparticles in stored red blood cells: an approach using flow cytometry and proteomic tools.
BACKGROUND AND OBJECTIVES Microparticles (MPs) are small phospholipid vesicles of less than 1 microm, shed in blood flow by various cell types. These MPs are involved in several biological processes and diseases. MPs have also been detected in blood products; however, their role in transfused patients is unknown. The purpose of this study was to characterize those MPs in blood bank conditions. ...
متن کاملBiochemical and cellular changes in leukocyte-depleted red blood cells stored for transfusion.
BACKGROUND To evaluate biochemical and cellular changes associated with the storage of leukocyte-depleted red blood cells (RBCs). METHODS We investigated 10 leukocyte-depleted RBC units, randomly chosen from volunteer donors. Every week an aliquot was collected for laboratorial evaluation, which included complete cell blood count, glucose-6-phosphate dehydrogenase (G6PD) activity, extracellul...
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ژورنال
عنوان ژورنال: Surgery
سال: 2018
ISSN: 0039-6060
DOI: 10.1016/j.surg.2017.09.028